Worldwide Esophageal Cancer Collaboration: clinical staging data
Identifieur interne : 001428 ( Main/Exploration ); précédent : 001427; suivant : 001429Worldwide Esophageal Cancer Collaboration: clinical staging data
Auteurs : T. W. Rice [États-Unis] ; C. Apperson-Hansen [États-Unis] ; L. M. Dipaola [États-Unis] ; M. E. Semple [États-Unis] ; T. E. M. R. Lerut [Belgique] ; M. B. Orringer [États-Unis] ; L.-Q. Chen [République populaire de Chine] ; W. L. Hofstetter [États-Unis] ; B. M. Smithers [Australie] ; V. W. Rusch [États-Unis] ; B. P. L. Wijnhoven [Pays-Bas] ; K. N. Chen [République populaire de Chine] ; A. R. Davies [Royaume-Uni] ; X. B. D Ourno [France] ; K. A. Kesler [États-Unis] ; J. D. Luketich [États-Unis] ; M. K. Ferguson [États-Unis] ; J. V. R S Nen [Finlande] ; R. Van Hillegersberg [Pays-Bas] ; W. Fang [République populaire de Chine] ; L. Durand [Argentine] ; W. H. Allum [Royaume-Uni] ; I. Cecconello [Brésil] ; R. J. Cerfolio [États-Unis] ; M. Pera [Espagne] ; S. M. Griffin [Royaume-Uni] ; R. Burger [Afrique du Sud] ; J.-F Liu [République populaire de Chine] ; M. S. Allen [États-Unis] ; S. Law [République populaire de Chine] ; T. J. Watson [États-Unis] ; G. E. Darling [Canada] ; W. J. Scott [États-Unis] ; A. Duranceau [Canada] ; C. E. Denlinger [États-Unis] ; P. H. Schipper [États-Unis] ; H. Ishwaran [États-Unis] ; E. H. Blackstone [États-Unis]Source :
- Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus [ 1120-8694 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Carcinomes (), Carcinomes (anatomopathologie), Carcinomes (mortalité), Collaboration intersectorielle, Femelle, Humains, Mâle, Oesophagectomie (mortalité), Pronostic, Stade de la tumeur (mortalité), Sujet âgé, Traitement néoadjuvant (mortalité), Tumeurs de l'oesophage (), Tumeurs de l'oesophage (anatomopathologie), Tumeurs de l'oesophage (mortalité), Évaluation des risques ().
- MESH :
- anatomopathologie : Carcinomes, Tumeurs de l'oesophage.
- mortalité : Carcinomes, Oesophagectomie, Stade de la tumeur, Traitement néoadjuvant, Tumeurs de l'oesophage.
- Adulte, Adulte d'âge moyen, Carcinomes, Collaboration intersectorielle, Femelle, Humains, Mâle, Pronostic, Sujet âgé, Tumeurs de l'oesophage, Évaluation des risques.
English descriptors
- KwdEn :
- Adult, Aged, Carcinoma (mortality), Carcinoma (pathology), Carcinoma (surgery), Carcinoma (therapy), Esophageal Neoplasms (mortality), Esophageal Neoplasms (pathology), Esophageal Neoplasms (surgery), Esophageal Neoplasms (therapy), Esophagectomy (mortality), Female, Humans, Intersectoral Collaboration, Male, Middle Aged, Neoadjuvant Therapy (mortality), Neoplasm Staging (mortality), Prognosis, Risk Assessment (methods).
- MESH :
- methods : Risk Assessment.
- mortality : Carcinoma, Esophageal Neoplasms, Esophagectomy, Neoadjuvant Therapy, Neoplasm Staging.
- pathology : Carcinoma, Esophageal Neoplasms.
- surgery : Carcinoma, Esophageal Neoplasms.
- therapy : Carcinoma, Esophageal Neoplasms.
- Adult, Aged, Female, Humans, Intersectoral Collaboration, Male, Middle Aged, Prognosis.
Abstract
To address uncertainty of whether clinical stage groupings (cTNM) for esophageal cancer share prognostic implications with pathologic groupings after esophagectomy alone (pTNM), we report data—simple descriptions of patient characteristics, cancer categories, and non-risk-adjusted survival—for clinically staged patients from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty-three institutions from six continents submitted data using variables with standard definitions: demographics, comorbidities, clinical cancer categories, and all-cause mortality from first management decision. Of 22,123 clinically staged patients, 8,156 had squamous cell carcinoma, 13,814 adenocarcinoma, 116 adenosquamous carcinoma, and 37 undifferentiated carcinoma. Patients were older (62 years) men (80%) with normal body mass index (18.5–25 mg/kg2, 47%), little weight loss (2.4 ± 7.8 kg), 0–1 ECOG performance status (67%), and history of smoking (67%). Cancers were cT1 (12%), cT2 (22%), cT3 (56%), cNO (44%), cMO (95%), and cG2–G3 (89%); most involved the distal esophagus (73%). Non-risk-adjusted survival for squamous cell carcinoma was not distinctive for early cT or cN; for adenocarcinoma, it was distinctive for early versus advanced cT and for cNO versus cN+. Patients with early cancers had worse survival and those with advanced cancers better survival than expected from equivalent pathologic categories based on prior WECC pathologic data. Thus, clinical and pathologic categories do not share prognostic implications. This makes clinically based treatment decisions difficult and pre-treatment prognostication inaccurate. These data will be the basis for the 8th edition cancer staging manuals following risk adjustment for patient characteristics, cancer categories, and treatment characteristics and should direct 9th edition data collection.
Url:
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591441
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528175
DOI: 10.1111/dote.12493
PubMed: 27731549
PubMed Central: 5591441
Affiliations:
- Afrique du Sud, Argentine, Australie, Belgique, Brésil, Canada, Espagne, Finlande, France, Pays-Bas, Royaume-Uni, République populaire de Chine, États-Unis
- Alabama, Angleterre, Caroline du Sud, Catalogne, Floride, Grand Londres, Hollande-Méridionale, Illinois, Indiana, Michigan, Minnesota, Ohio, Oregon, Pennsylvanie, Provence-Alpes-Côte d'Azur, Texas, Utrecht (province), État de New York, État de São Paulo
- Barcelone, Londres, Marseille, Pékin, Rotterdam, São Paulo, Utrecht
- Université de São Paulo
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Le document en format XML
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Fang</name><affiliation wicri:level="1"><nlm:aff id="A18">Shanghai Chest Hospital, Shanghai, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Chest Hospital, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Durand, L" sort="Durand, L" uniqKey="Durand L" first="L." last="Durand">L. Durand</name><affiliation wicri:level="1"><nlm:aff id="A19">Hospital de Clinicas, University of Buenos Aires, Buenos Aires, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Hospital de Clinicas, University of Buenos Aires, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Allum, W H" sort="Allum, W H" uniqKey="Allum W" first="W. H." last="Allum">W. H. Allum</name><affiliation wicri:level="3"><nlm:aff id="A20">Royal Marsden NHS Foundation Trust, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Marsden NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Cecconello, I" sort="Cecconello, I" uniqKey="Cecconello I" first="I." last="Cecconello">I. Cecconello</name><affiliation wicri:level="4"><nlm:aff id="A21">University of São Paulo, São Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>University of São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Cerfolio, R J" sort="Cerfolio, R J" uniqKey="Cerfolio R" first="R. J." last="Cerfolio">R. J. Cerfolio</name><affiliation wicri:level="2"><nlm:aff id="A22">University of Alabama at Birmingham, Birmingham, Alabama, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Alabama at Birmingham, Birmingham, Alabama</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Pera, M" sort="Pera, M" uniqKey="Pera M" first="M." last="Pera">M. Pera</name><affiliation wicri:level="3"><nlm:aff id="A23">Hospital Universitario del Mar, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario del Mar, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Griffin, S M" sort="Griffin, S M" uniqKey="Griffin S" first="S. M." last="Griffin">S. M. Griffin</name><affiliation wicri:level="1"><nlm:aff id="A24">University of Newcastle upon Tyne, Newcastle, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Newcastle upon Tyne, Newcastle</wicri:regionArea><wicri:noRegion>Newcastle</wicri:noRegion></affiliation></author><author><name sortKey="Burger, R" sort="Burger, R" uniqKey="Burger R" first="R." last="Burger">R. Burger</name><affiliation wicri:level="1"><nlm:aff id="A25">Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Groote Schuur Hospital, University of Cape Town, Cape Town</wicri:regionArea><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Liu, J F" sort="Liu, J F" uniqKey="Liu J" first="J.-F" last="Liu">J.-F Liu</name><affiliation wicri:level="1"><nlm:aff id="A26">Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei</wicri:regionArea><wicri:noRegion>Hebei</wicri:noRegion></affiliation></author><author><name sortKey="Allen, M S" sort="Allen, M S" uniqKey="Allen M" first="M. S." last="Allen">M. S. Allen</name><affiliation wicri:level="2"><nlm:aff id="A27">Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Law, S" sort="Law, S" uniqKey="Law S" first="S." last="Law">S. Law</name><affiliation wicri:level="1"><nlm:aff id="A28">University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Watson, T J" sort="Watson, T J" uniqKey="Watson T" first="T. J." last="Watson">T. J. Watson</name><affiliation wicri:level="2"><nlm:aff id="A29">University of Rochester, Rochester, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Rochester, Rochester, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Darling, G E" sort="Darling, G E" uniqKey="Darling G" first="G. E." last="Darling">G. E. Darling</name><affiliation wicri:level="1"><nlm:aff id="A30">Toronto General Hospital, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto General Hospital, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Scott, W J" sort="Scott, W J" uniqKey="Scott W" first="W. J." last="Scott">W. J. Scott</name><affiliation wicri:level="2"><nlm:aff id="A31">Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fox Chase Cancer Center, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Duranceau, A" sort="Duranceau, A" uniqKey="Duranceau A" first="A." last="Duranceau">A. Duranceau</name><affiliation wicri:level="1"><nlm:aff id="A32">University of Montreal, Montreal, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>University of Montreal, Montreal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Denlinger, C E" sort="Denlinger, C E" uniqKey="Denlinger C" first="C. E." last="Denlinger">C. E. Denlinger</name><affiliation wicri:level="2"><nlm:aff id="A33">Medical University of South Carolina, Charleston, South Carolina, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medical University of South Carolina, Charleston, South Carolina</wicri:regionArea><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author><author><name sortKey="Schipper, P H" sort="Schipper, P H" uniqKey="Schipper P" first="P. H." last="Schipper">P. H. Schipper</name><affiliation wicri:level="2"><nlm:aff id="A34">Oregon Health and Science University, Portland, Oregon, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Oregon Health and Science University, Portland, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Ishwaran, H" sort="Ishwaran, H" uniqKey="Ishwaran H" first="H." last="Ishwaran">H. Ishwaran</name><affiliation wicri:level="2"><nlm:aff id="A35">University of Miami, Miami, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Blackstone, E H" sort="Blackstone, E H" uniqKey="Blackstone E" first="E. H." last="Blackstone">E. H. Blackstone</name><affiliation wicri:level="2"><nlm:aff id="A1">Cleveland Clinic, Cleveland, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cleveland Clinic, Cleveland, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27731549</idno><idno type="pmc">5591441</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591441</idno><idno type="RBID">PMC:5591441</idno><idno type="doi">10.1111/dote.12493</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002057</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002057</idno><idno type="wicri:Area/Pmc/Curation">001F11</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001F11</idno><idno type="wicri:Area/Pmc/Checkpoint">000485</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000485</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001800</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001800</idno><idno type="wicri:Area/PubMed/Curation">001777</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001777</idno><idno type="wicri:Area/PubMed/Checkpoint">001777</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001777</idno><idno type="wicri:Area/Ncbi/Merge">003C97</idno><idno type="wicri:Area/Ncbi/Curation">003C97</idno><idno type="wicri:Area/Ncbi/Checkpoint">003C97</idno><idno type="wicri:doubleKey">1120-8694:2016:Rice T:worldwide:esophageal:cancer</idno><idno type="wicri:Area/Main/Merge">001423</idno><idno type="wicri:source">PMC</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528175</idno><idno type="RBID">PMC:5528175</idno><idno type="wicri:Area/Pmc/Corpus">002056</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002056</idno><idno type="wicri:Area/Pmc/Curation">001F10</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001F10</idno><idno type="wicri:Area/Pmc/Checkpoint">000484</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000484</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001723</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001723</idno><idno type="wicri:Area/PubMed/Curation">001700</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001700</idno><idno type="wicri:Area/PubMed/Checkpoint">001700</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001700</idno><idno type="wicri:Area/Ncbi/Merge">003C96</idno><idno type="wicri:Area/Ncbi/Curation">003C96</idno><idno type="wicri:Area/Ncbi/Checkpoint">003C96</idno><idno type="wicri:doubleKey">1120-8694:2016:Rice T:worldwide:esophageal:cancer</idno><idno type="wicri:Area/Main/Merge">001422</idno><idno type="wicri:Area/Main/Curation">001428</idno><idno type="wicri:Area/Main/Exploration">001428</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Worldwide Esophageal Cancer Collaboration: clinical staging data</title><author><name sortKey="Rice, T W" sort="Rice, T W" uniqKey="Rice T" first="T. W." last="Rice">T. W. Rice</name><affiliation wicri:level="2"><nlm:aff id="A1">Cleveland Clinic, Cleveland, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cleveland Clinic, Cleveland, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Apperson Hansen, C" sort="Apperson Hansen, C" uniqKey="Apperson Hansen C" first="C." last="Apperson-Hansen">C. Apperson-Hansen</name><affiliation wicri:level="2"><nlm:aff id="A2">Case Western Reserve University, Cleveland, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Case Western Reserve University, Cleveland, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Dipaola, L M" sort="Dipaola, L M" uniqKey="Dipaola L" first="L. M." last="Dipaola">L. M. Dipaola</name><affiliation wicri:level="2"><nlm:aff id="A1">Cleveland Clinic, Cleveland, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cleveland Clinic, Cleveland, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Semple, M E" sort="Semple, M E" uniqKey="Semple M" first="M. E." last="Semple">M. E. Semple</name><affiliation wicri:level="2"><nlm:aff id="A1">Cleveland Clinic, Cleveland, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cleveland Clinic, Cleveland, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Lerut, T E M R" sort="Lerut, T E M R" uniqKey="Lerut T" first="T. E. M. R." last="Lerut">T. E. M. R. Lerut</name><affiliation wicri:level="1"><nlm:aff id="A3">University Ziekenhuizen Leuven, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>University Ziekenhuizen Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Orringer, M B" sort="Orringer, M B" uniqKey="Orringer M" first="M. B." last="Orringer">M. B. Orringer</name><affiliation wicri:level="2"><nlm:aff id="A4">University of Michigan, Ann Arbor, Michigan, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Michigan, Ann Arbor, Michigan</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Chen, L Q" sort="Chen, L Q" uniqKey="Chen L" first="L.-Q." last="Chen">L.-Q. Chen</name><affiliation wicri:level="1"><nlm:aff id="A5">West China Hospital of Sichuan University, Chengdu, Sichuan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>West China Hospital of Sichuan University, Chengdu, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Hofstetter, W L" sort="Hofstetter, W L" uniqKey="Hofstetter W" first="W. L." last="Hofstetter">W. L. Hofstetter</name><affiliation wicri:level="2"><nlm:aff id="A6">University of Texas MD Anderson Hospital, Houston, Texas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Texas MD Anderson Hospital, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Smithers, B M" sort="Smithers, B M" uniqKey="Smithers B" first="B. M." last="Smithers">B. M. Smithers</name><affiliation wicri:level="1"><nlm:aff id="A7">University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Rusch, V W" sort="Rusch, V W" uniqKey="Rusch V" first="V. W." last="Rusch">V. W. Rusch</name><affiliation wicri:level="2"><nlm:aff id="A8">Memorial Sloan-Kettering Cancer Center, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Wijnhoven, B P L" sort="Wijnhoven, B P L" uniqKey="Wijnhoven B" first="B. P. L." last="Wijnhoven">B. P. L. Wijnhoven</name><affiliation wicri:level="3"><nlm:aff id="A9">Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Chen, K N" sort="Chen, K N" uniqKey="Chen K" first="K. N." last="Chen">K. N. Chen</name><affiliation wicri:level="3"><nlm:aff id="A10">Beijing Cancer Hospital, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Cancer Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Davies, A R" sort="Davies, A R" uniqKey="Davies A" first="A. R." last="Davies">A. R. Davies</name><affiliation wicri:level="3"><nlm:aff id="A11">Guy’s & St Thomas’ Hospitals, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Guy’s & St Thomas’ Hospitals, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="D Ourno, X B" sort="D Ourno, X B" uniqKey="D Ourno X" first="X. B." last="D Ourno">X. B. D Ourno</name><affiliation wicri:level="3"><nlm:aff id="A12">Hôpital Nord, Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Nord, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Kesler, K A" sort="Kesler, K A" uniqKey="Kesler K" first="K. A." last="Kesler">K. A. Kesler</name><affiliation wicri:level="2"><nlm:aff id="A13">Indiana University Medical Center, Indianapolis, Indiana, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Indiana University Medical Center, Indianapolis, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Luketich, J D" sort="Luketich, J D" uniqKey="Luketich J" first="J. D." last="Luketich">J. D. Luketich</name><affiliation wicri:level="2"><nlm:aff id="A14">University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Ferguson, M K" sort="Ferguson, M K" uniqKey="Ferguson M" first="M. K." last="Ferguson">M. K. Ferguson</name><affiliation wicri:level="2"><nlm:aff id="A15">Department of Surgery, The University of Chicago, Chicago, Illinois, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, The University of Chicago, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="R S Nen, J V" sort="R S Nen, J V" uniqKey="R S Nen J" first="J. V." last="R S Nen">J. V. R S Nen</name><affiliation wicri:level="1"><nlm:aff id="A16">Helsinki University Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki University Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Van Hillegersberg, R" sort="Van Hillegersberg, R" uniqKey="Van Hillegersberg R" first="R." last="Van Hillegersberg">R. Van Hillegersberg</name><affiliation wicri:level="3"><nlm:aff id="A17">University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Fang, W" sort="Fang, W" uniqKey="Fang W" first="W." last="Fang">W. Fang</name><affiliation wicri:level="1"><nlm:aff id="A18">Shanghai Chest Hospital, Shanghai, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Chest Hospital, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Durand, L" sort="Durand, L" uniqKey="Durand L" first="L." last="Durand">L. Durand</name><affiliation wicri:level="1"><nlm:aff id="A19">Hospital de Clinicas, University of Buenos Aires, Buenos Aires, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Hospital de Clinicas, University of Buenos Aires, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Allum, W H" sort="Allum, W H" uniqKey="Allum W" first="W. H." last="Allum">W. H. Allum</name><affiliation wicri:level="3"><nlm:aff id="A20">Royal Marsden NHS Foundation Trust, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Marsden NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Cecconello, I" sort="Cecconello, I" uniqKey="Cecconello I" first="I." last="Cecconello">I. Cecconello</name><affiliation wicri:level="4"><nlm:aff id="A21">University of São Paulo, São Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>University of São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Cerfolio, R J" sort="Cerfolio, R J" uniqKey="Cerfolio R" first="R. J." last="Cerfolio">R. J. Cerfolio</name><affiliation wicri:level="2"><nlm:aff id="A22">University of Alabama at Birmingham, Birmingham, Alabama, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Alabama at Birmingham, Birmingham, Alabama</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Pera, M" sort="Pera, M" uniqKey="Pera M" first="M." last="Pera">M. Pera</name><affiliation wicri:level="3"><nlm:aff id="A23">Hospital Universitario del Mar, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario del Mar, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Griffin, S M" sort="Griffin, S M" uniqKey="Griffin S" first="S. M." last="Griffin">S. M. Griffin</name><affiliation wicri:level="1"><nlm:aff id="A24">University of Newcastle upon Tyne, Newcastle, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Newcastle upon Tyne, Newcastle</wicri:regionArea><wicri:noRegion>Newcastle</wicri:noRegion></affiliation></author><author><name sortKey="Burger, R" sort="Burger, R" uniqKey="Burger R" first="R." last="Burger">R. Burger</name><affiliation wicri:level="1"><nlm:aff id="A25">Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Groote Schuur Hospital, University of Cape Town, Cape Town</wicri:regionArea><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Liu, J F" sort="Liu, J F" uniqKey="Liu J" first="J.-F" last="Liu">J.-F Liu</name><affiliation wicri:level="1"><nlm:aff id="A26">Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei</wicri:regionArea><wicri:noRegion>Hebei</wicri:noRegion></affiliation></author><author><name sortKey="Allen, M S" sort="Allen, M S" uniqKey="Allen M" first="M. S." last="Allen">M. S. Allen</name><affiliation wicri:level="2"><nlm:aff id="A27">Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Law, S" sort="Law, S" uniqKey="Law S" first="S." last="Law">S. Law</name><affiliation wicri:level="1"><nlm:aff id="A28">University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Watson, T J" sort="Watson, T J" uniqKey="Watson T" first="T. J." last="Watson">T. J. Watson</name><affiliation wicri:level="2"><nlm:aff id="A29">University of Rochester, Rochester, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Rochester, Rochester, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Darling, G E" sort="Darling, G E" uniqKey="Darling G" first="G. E." last="Darling">G. E. Darling</name><affiliation wicri:level="1"><nlm:aff id="A30">Toronto General Hospital, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto General Hospital, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Scott, W J" sort="Scott, W J" uniqKey="Scott W" first="W. J." last="Scott">W. J. Scott</name><affiliation wicri:level="2"><nlm:aff id="A31">Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fox Chase Cancer Center, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Duranceau, A" sort="Duranceau, A" uniqKey="Duranceau A" first="A." last="Duranceau">A. Duranceau</name><affiliation wicri:level="1"><nlm:aff id="A32">University of Montreal, Montreal, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>University of Montreal, Montreal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Denlinger, C E" sort="Denlinger, C E" uniqKey="Denlinger C" first="C. E." last="Denlinger">C. E. Denlinger</name><affiliation wicri:level="2"><nlm:aff id="A33">Medical University of South Carolina, Charleston, South Carolina, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medical University of South Carolina, Charleston, South Carolina</wicri:regionArea><placeName><region type="state">Caroline du Sud</region></placeName></affiliation></author><author><name sortKey="Schipper, P H" sort="Schipper, P H" uniqKey="Schipper P" first="P. H." last="Schipper">P. H. Schipper</name><affiliation wicri:level="2"><nlm:aff id="A34">Oregon Health and Science University, Portland, Oregon, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Oregon Health and Science University, Portland, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Ishwaran, H" sort="Ishwaran, H" uniqKey="Ishwaran H" first="H." last="Ishwaran">H. Ishwaran</name><affiliation wicri:level="2"><nlm:aff id="A35">University of Miami, Miami, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Blackstone, E H" sort="Blackstone, E H" uniqKey="Blackstone E" first="E. H." last="Blackstone">E. H. Blackstone</name><affiliation wicri:level="2"><nlm:aff id="A1">Cleveland Clinic, Cleveland, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cleveland Clinic, Cleveland, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author></analytic><series><title level="j">Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus</title><idno type="ISSN">1120-8694</idno><idno type="eISSN">1442-2050</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Carcinoma (mortality)</term><term>Carcinoma (pathology)</term><term>Carcinoma (surgery)</term><term>Carcinoma (therapy)</term><term>Esophageal Neoplasms (mortality)</term><term>Esophageal Neoplasms (pathology)</term><term>Esophageal Neoplasms (surgery)</term><term>Esophageal Neoplasms (therapy)</term><term>Esophagectomy (mortality)</term><term>Female</term><term>Humans</term><term>Intersectoral Collaboration</term><term>Male</term><term>Middle Aged</term><term>Neoadjuvant Therapy (mortality)</term><term>Neoplasm Staging (mortality)</term><term>Prognosis</term><term>Risk Assessment (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Carcinomes ()</term><term>Carcinomes (anatomopathologie)</term><term>Carcinomes (mortalité)</term><term>Collaboration intersectorielle</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Oesophagectomie (mortalité)</term><term>Pronostic</term><term>Stade de la tumeur (mortalité)</term><term>Sujet âgé</term><term>Traitement néoadjuvant (mortalité)</term><term>Tumeurs de l'oesophage ()</term><term>Tumeurs de l'oesophage (anatomopathologie)</term><term>Tumeurs de l'oesophage (mortalité)</term><term>Évaluation des risques ()</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinomes</term><term>Tumeurs de l'oesophage</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Risk Assessment</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Carcinoma</term><term>Esophageal Neoplasms</term><term>Esophagectomy</term><term>Neoadjuvant Therapy</term><term>Neoplasm Staging</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Carcinomes</term><term>Oesophagectomie</term><term>Stade de la tumeur</term><term>Traitement néoadjuvant</term><term>Tumeurs de l'oesophage</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma</term><term>Esophageal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Carcinoma</term><term>Esophageal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Carcinoma</term><term>Esophageal Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Intersectoral Collaboration</term><term>Male</term><term>Middle Aged</term><term>Prognosis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Carcinomes</term><term>Collaboration intersectorielle</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pronostic</term><term>Sujet âgé</term><term>Tumeurs de l'oesophage</term><term>Évaluation des risques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>SUMMARY</title><p id="P1">To address uncertainty of whether clinical stage groupings (cTNM) for esophageal cancer share prognostic implications with pathologic groupings after esophagectomy alone (pTNM), we report data—simple descriptions of patient characteristics, cancer categories, and non-risk-adjusted survival—for clinically staged patients from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty-three institutions from six continents submitted data using variables with standard definitions: demographics, comorbidities, clinical cancer categories, and all-cause mortality from first management decision. Of 22,123 clinically staged patients, 8,156 had squamous cell carcinoma, 13,814 adenocarcinoma, 116 adenosquamous carcinoma, and 37 undifferentiated carcinoma. Patients were older (62 years) men (80%) with normal body mass index (18.5–25 mg/kg<sup>2</sup>, 47%), little weight loss (2.4 ± 7.8 kg), 0–1 ECOG performance status (67%), and history of smoking (67%). Cancers were cT1 (12%), cT2 (22%), cT3 (56%), cNO (44%), cMO (95%), and cG2–G3 (89%); most involved the distal esophagus (73%). Non-risk-adjusted survival for squamous cell carcinoma was not distinctive for early cT or cN; for adenocarcinoma, it was distinctive for early versus advanced cT and for cNO versus cN+. Patients with early cancers had worse survival and those with advanced cancers better survival than expected from equivalent pathologic categories based on prior WECC pathologic data. Thus, clinical and pathologic categories do not share prognostic implications. This makes clinically based treatment decisions difficult and pre-treatment prognostication inaccurate. These data will be the basis for the 8th edition cancer staging manuals following risk adjustment for patient characteristics, cancer categories, and treatment characteristics and should direct 9th edition data collection.</p></div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Argentine</li><li>Australie</li><li>Belgique</li><li>Brésil</li><li>Canada</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Alabama</li><li>Angleterre</li><li>Caroline du Sud</li><li>Catalogne</li><li>Floride</li><li>Grand Londres</li><li>Hollande-Méridionale</li><li>Illinois</li><li>Indiana</li><li>Michigan</li><li>Minnesota</li><li>Ohio</li><li>Oregon</li><li>Pennsylvanie</li><li>Provence-Alpes-Côte d'Azur</li><li>Texas</li><li>Utrecht (province)</li><li>État de New York</li><li>État de São Paulo</li></region><settlement><li>Barcelone</li><li>Londres</li><li>Marseille</li><li>Pékin</li><li>Rotterdam</li><li>São Paulo</li><li>Utrecht</li></settlement><orgName><li>Université de São Paulo</li></orgName></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Rice, T W" sort="Rice, T W" uniqKey="Rice T" first="T. W." last="Rice">T. W. Rice</name></region><name sortKey="Allen, M S" sort="Allen, M S" uniqKey="Allen M" first="M. S." last="Allen">M. S. Allen</name><name sortKey="Apperson Hansen, C" sort="Apperson Hansen, C" uniqKey="Apperson Hansen C" first="C." last="Apperson-Hansen">C. Apperson-Hansen</name><name sortKey="Blackstone, E H" sort="Blackstone, E H" uniqKey="Blackstone E" first="E. H." last="Blackstone">E. H. Blackstone</name><name sortKey="Cerfolio, R J" sort="Cerfolio, R J" uniqKey="Cerfolio R" first="R. J." last="Cerfolio">R. J. Cerfolio</name><name sortKey="Denlinger, C E" sort="Denlinger, C E" uniqKey="Denlinger C" first="C. E." last="Denlinger">C. E. Denlinger</name><name sortKey="Dipaola, L M" sort="Dipaola, L M" uniqKey="Dipaola L" first="L. M." last="Dipaola">L. M. Dipaola</name><name sortKey="Ferguson, M K" sort="Ferguson, M K" uniqKey="Ferguson M" first="M. K." last="Ferguson">M. K. Ferguson</name><name sortKey="Hofstetter, W L" sort="Hofstetter, W L" uniqKey="Hofstetter W" first="W. L." last="Hofstetter">W. L. Hofstetter</name><name sortKey="Ishwaran, H" sort="Ishwaran, H" uniqKey="Ishwaran H" first="H." last="Ishwaran">H. Ishwaran</name><name sortKey="Kesler, K A" sort="Kesler, K A" uniqKey="Kesler K" first="K. A." last="Kesler">K. A. Kesler</name><name sortKey="Luketich, J D" sort="Luketich, J D" uniqKey="Luketich J" first="J. D." last="Luketich">J. D. Luketich</name><name sortKey="Orringer, M B" sort="Orringer, M B" uniqKey="Orringer M" first="M. B." last="Orringer">M. B. Orringer</name><name sortKey="Rusch, V W" sort="Rusch, V W" uniqKey="Rusch V" first="V. W." last="Rusch">V. W. Rusch</name><name sortKey="Schipper, P H" sort="Schipper, P H" uniqKey="Schipper P" first="P. H." last="Schipper">P. H. Schipper</name><name sortKey="Scott, W J" sort="Scott, W J" uniqKey="Scott W" first="W. J." last="Scott">W. J. Scott</name><name sortKey="Semple, M E" sort="Semple, M E" uniqKey="Semple M" first="M. E." last="Semple">M. E. Semple</name><name sortKey="Watson, T J" sort="Watson, T J" uniqKey="Watson T" first="T. J." last="Watson">T. J. Watson</name></country><country name="Belgique"><noRegion><name sortKey="Lerut, T E M R" sort="Lerut, T E M R" uniqKey="Lerut T" first="T. E. M. R." last="Lerut">T. E. M. R. Lerut</name></noRegion></country><country name="République populaire de Chine"><noRegion><name sortKey="Chen, L Q" sort="Chen, L Q" uniqKey="Chen L" first="L.-Q." last="Chen">L.-Q. Chen</name></noRegion><name sortKey="Chen, K N" sort="Chen, K N" uniqKey="Chen K" first="K. N." last="Chen">K. N. Chen</name><name sortKey="Fang, W" sort="Fang, W" uniqKey="Fang W" first="W." last="Fang">W. Fang</name><name sortKey="Law, S" sort="Law, S" uniqKey="Law S" first="S." last="Law">S. Law</name><name sortKey="Liu, J F" sort="Liu, J F" uniqKey="Liu J" first="J.-F" last="Liu">J.-F Liu</name></country><country name="Australie"><noRegion><name sortKey="Smithers, B M" sort="Smithers, B M" uniqKey="Smithers B" first="B. M." last="Smithers">B. M. Smithers</name></noRegion></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Wijnhoven, B P L" sort="Wijnhoven, B P L" uniqKey="Wijnhoven B" first="B. P. L." last="Wijnhoven">B. P. L. Wijnhoven</name></region><name sortKey="Van Hillegersberg, R" sort="Van Hillegersberg, R" uniqKey="Van Hillegersberg R" first="R." last="Van Hillegersberg">R. Van Hillegersberg</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Davies, A R" sort="Davies, A R" uniqKey="Davies A" first="A. R." last="Davies">A. R. Davies</name></region><name sortKey="Allum, W H" sort="Allum, W H" uniqKey="Allum W" first="W. H." last="Allum">W. H. Allum</name><name sortKey="Griffin, S M" sort="Griffin, S M" uniqKey="Griffin S" first="S. M." last="Griffin">S. M. Griffin</name></country><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="D Ourno, X B" sort="D Ourno, X B" uniqKey="D Ourno X" first="X. B." last="D Ourno">X. B. D Ourno</name></region></country><country name="Finlande"><noRegion><name sortKey="R S Nen, J V" sort="R S Nen, J V" uniqKey="R S Nen J" first="J. V." last="R S Nen">J. V. R S Nen</name></noRegion></country><country name="Argentine"><noRegion><name sortKey="Durand, L" sort="Durand, L" uniqKey="Durand L" first="L." last="Durand">L. Durand</name></noRegion></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="Cecconello, I" sort="Cecconello, I" uniqKey="Cecconello I" first="I." last="Cecconello">I. Cecconello</name></region></country><country name="Espagne"><region name="Catalogne"><name sortKey="Pera, M" sort="Pera, M" uniqKey="Pera M" first="M." last="Pera">M. Pera</name></region></country><country name="Afrique du Sud"><noRegion><name sortKey="Burger, R" sort="Burger, R" uniqKey="Burger R" first="R." last="Burger">R. Burger</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Darling, G E" sort="Darling, G E" uniqKey="Darling G" first="G. E." last="Darling">G. E. Darling</name></noRegion><name sortKey="Duranceau, A" sort="Duranceau, A" uniqKey="Duranceau A" first="A." last="Duranceau">A. Duranceau</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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